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SIRT1 can also regulate the function of PGC-1 in cells by regulating the acetylation and activity level of PGC-1, as well as regulation of downstream transcription factors such as nuclear receptor peroxisome proliferator-activated receptor (PPAR), estrogen-related receptor (ERR), nuclear respiratory factor (NRFs), and mitochondrial transcription factor A (Tfam), further affecting mitochondrial production and function [17, 18], and regulating the metabolism of glucose and lipids [19]

These benefits include: Supporting fertility, improving feelings of anxiety or depression, benefits brain health and memory, supports hair, skin and nails, and more

PMCID: PMC8566728.